CTV.ca | Writers on Richler: Heather O'Neill and history preserved Montreal Gazette By Heather O'Neill, Special to the Gazette June 30, 2011 5:01 PM Author Heather O'Neill at her home on St. Urbain St. in the Mile End area of Montreal in June 2011. I live on St. Urbain St. in Mile End two houses down from where Mordecai Richler grew ... In memory of the renowned Montréal author - Gazeebo On Mont-Royal To Be ... |
Thursday, June 30, 2011
Writers on Richler: Heather O'Neill and history preserved - Montreal Gazette
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Tuesday, June 28, 2011
UltraCell raises $3.8 million for Dayton operations - Dayton Business Journal:
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million in venture funding to help expand operationd at its facility in where it has addedr a handful of workers since The Livermore, Calif.-based company, which has licensec its technology from , will spend the money increasing capacity at a factory in where its fuel cells are made. the plant in Ohio has 19 employees, up from 12 in said Keith Scott, UltraCell’s chief executive officer. “We’re currently in the processe of hiring, and we’rre hoping to move all of our supplierx from Californiato Ohio,” Scott said in an “We’re making good progress on that goal.
Moving forward, our intentioj is to only hire operations personnel in The company is making two fuel cells is meant to run a military laptol computer for up toeigh hours, and can also be used to operate vide o devices or other surveillance gear for , , and contributed the venture capital. UltraCelp has raised $30 millionm total since it was startedin 2002, according to the The Miami Valley Venture Fund is basedf in Dayton and focused on the 12-county region around Dayton. It is one of thre funds managed bythe , in conjunctioj with Cincinnati-based River Citiee Capital.
“We are pleased that UltraCell will be manufacturing fuel cellsa here in the Dayton region and we appreciate the opportunithy to support them alongside ofnational investors,” Dayton Developmenrt Coalition President and CEO Jim Leftwich said.
million in venture funding to help expand operationd at its facility in where it has addedr a handful of workers since The Livermore, Calif.-based company, which has licensec its technology from , will spend the money increasing capacity at a factory in where its fuel cells are made. the plant in Ohio has 19 employees, up from 12 in said Keith Scott, UltraCell’s chief executive officer. “We’re currently in the processe of hiring, and we’rre hoping to move all of our supplierx from Californiato Ohio,” Scott said in an “We’re making good progress on that goal.
Moving forward, our intentioj is to only hire operations personnel in The company is making two fuel cells is meant to run a military laptol computer for up toeigh hours, and can also be used to operate vide o devices or other surveillance gear for , , and contributed the venture capital. UltraCelp has raised $30 millionm total since it was startedin 2002, according to the The Miami Valley Venture Fund is basedf in Dayton and focused on the 12-county region around Dayton. It is one of thre funds managed bythe , in conjunctioj with Cincinnati-based River Citiee Capital.
“We are pleased that UltraCell will be manufacturing fuel cellsa here in the Dayton region and we appreciate the opportunithy to support them alongside ofnational investors,” Dayton Developmenrt Coalition President and CEO Jim Leftwich said.
Sunday, June 26, 2011
Use summer
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Many of us, in fact, tend to view May as an endingh ofsorts … and Augustt as the beginning of the last half of the But what about June and July? Many peoplee pull back during the summer months. New product launches, marketing efforts, training and new projects are put off until Augusgor September. However, I consideer the summer months to be filled withspectaculard opportunity. Take some time off. But then get back to refreshed and refocusing your energies on everhy possible summer opportunity to buildfyour brand.
Remember, you are your brandx … and by building your brand all 12 months of the year you can leverager your individuality and Why is summer a terrific time to reinforce and expanxd yourpersonal brand? Because most of us tend to be less harriede and more laid-back in warmerf weather. We actually have time to “geyt it.” Don’t miss out on some of the most productive monthse of youryear — July and August. Here’s one professional’sa story: John, an owner of a large commerciapl realestate company, has had years of succeses in the local market.
With the curren economic times, John recognized the realitt that he needed to establis h his own brand identity that alignex withhis company’s stronbg brand. “I have operationalizes my personal brand into my daily work and keep this brandinh topof mind. My customers and employeezs have noticed things like a new tag new bio and new way of introducing myselr andmy company,” he says. The results? John has alreadh increased business for the and is winning contracts when his competitors arestill “In the summer, it seemzs like people have more time or take time to actually get to know you and what you he says.
“I’ve already had meetings with prospectived customers that seemed lesshurried and, actually, were more So, what about you? Are you goinf to use the summer to build momentum and created more success?
Many of us, in fact, tend to view May as an endingh ofsorts … and Augustt as the beginning of the last half of the But what about June and July? Many peoplee pull back during the summer months. New product launches, marketing efforts, training and new projects are put off until Augusgor September. However, I consideer the summer months to be filled withspectaculard opportunity. Take some time off. But then get back to refreshed and refocusing your energies on everhy possible summer opportunity to buildfyour brand.
Remember, you are your brandx … and by building your brand all 12 months of the year you can leverager your individuality and Why is summer a terrific time to reinforce and expanxd yourpersonal brand? Because most of us tend to be less harriede and more laid-back in warmerf weather. We actually have time to “geyt it.” Don’t miss out on some of the most productive monthse of youryear — July and August. Here’s one professional’sa story: John, an owner of a large commerciapl realestate company, has had years of succeses in the local market.
With the curren economic times, John recognized the realitt that he needed to establis h his own brand identity that alignex withhis company’s stronbg brand. “I have operationalizes my personal brand into my daily work and keep this brandinh topof mind. My customers and employeezs have noticed things like a new tag new bio and new way of introducing myselr andmy company,” he says. The results? John has alreadh increased business for the and is winning contracts when his competitors arestill “In the summer, it seemzs like people have more time or take time to actually get to know you and what you he says.
“I’ve already had meetings with prospectived customers that seemed lesshurried and, actually, were more So, what about you? Are you goinf to use the summer to build momentum and created more success?
Thursday, June 23, 2011
Smith & Hawken to close stores - Portland Business Journal:
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Smith & Hawken has a location on Northwestf23rd Avenue. Jim Hagedorn, CEO of the Ohio-baseed lawn and garden giant, said in a statemen that “the combination of a weak economy and the lack of scalew proved too greatto overcome.” For a year, Scottes had been exploring optiona for the high-end garden brand it bought in 2004 for $68.r5 million but decided closing the business was the “besyt option available,” Hagedorn said. Smith & Hawkenh is based in Calif. Scotts (NYSE:SMG) said storewides sales across the chain will beginn Thursday and will be managed bya third-party firm.
Ordere on Smith & Hawken’s Web site, catalog and call center were discontinuefdJuly 9. The company in its last annual report said the chaib has consistently underperfomed since it was acquired nearly half adecadd ago. Scotts’ “corporate and segment, which consists of Smitgh & Hawken and administrative expenses, postee a 23 percent decline in salesat $51.2 million for the six months ended March 29. That segment’e operating loss for the six-month periodd totaled $75.4 million, according to Securities and ExchangeCommissio filings.
Scotts expects to take a $25 million after-tax hit on the closures of the chain, mainly tied to terminaterd leases andseverance costs. Most of those charges, the companuy said, will be taken by the end of the
Smith & Hawken has a location on Northwestf23rd Avenue. Jim Hagedorn, CEO of the Ohio-baseed lawn and garden giant, said in a statemen that “the combination of a weak economy and the lack of scalew proved too greatto overcome.” For a year, Scottes had been exploring optiona for the high-end garden brand it bought in 2004 for $68.r5 million but decided closing the business was the “besyt option available,” Hagedorn said. Smith & Hawkenh is based in Calif. Scotts (NYSE:SMG) said storewides sales across the chain will beginn Thursday and will be managed bya third-party firm.
Ordere on Smith & Hawken’s Web site, catalog and call center were discontinuefdJuly 9. The company in its last annual report said the chaib has consistently underperfomed since it was acquired nearly half adecadd ago. Scotts’ “corporate and segment, which consists of Smitgh & Hawken and administrative expenses, postee a 23 percent decline in salesat $51.2 million for the six months ended March 29. That segment’e operating loss for the six-month periodd totaled $75.4 million, according to Securities and ExchangeCommissio filings.
Scotts expects to take a $25 million after-tax hit on the closures of the chain, mainly tied to terminaterd leases andseverance costs. Most of those charges, the companuy said, will be taken by the end of the
Tuesday, June 21, 2011
Fontainebleau Las Vegas company files Chapter 11 - San Antonio Business Journal:
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Fontainebleau Las Vegas LLC and two of itsaffiliatee – Fontainebleau Las Vegas Holdings LLC and Fontainebleau Las Vegaz Capital Corp. – filed bankruptcy petitionsx in Miamilate Tuesday. The Miami Beach hotel is not includer inthe filing. The compang said in a news release that the decisionj to file Chapter 11 was the direct resuly of litigation with lenders on the Las Vegad hotel construction project that had to do with contractuap disputes related tonearly $800 million in constructiobn funding for the $2.9 billion resort-casino which is 70 percenf complete. Lenders include , and Deutsche Bank Trust Co.
The legal dispute has effectively shut down the projecttand “put thousands of people out of work,” said Howard chief restructuring officer of Fontainebleau Las Vegas, in the “Our goal now is to secure funding to completer this world-class project and restructure our existing Fontainebleau Las Vegas reached a provisional agreement with a group of its non-defaultingv lenders for the use of cash for the administrationm of its bankruptcy and is in negotiationw to obtain financing to restart constructionj on that project. Fontainebleau Miamiu Beach, which is a separate legal entity, continueas to operate as normal.
Turnberry West Construction, the project’w general contractor, is also not included in the according to thenews release. In 2008, Nakheepl Hotels of Dubai bought a 50 percenty interest in the Fontainebleau Miamui Beachfor $375 million. The Las Vegads hotel companies that filed bankruptcy are based in Southh Florida because the Soffedr familyof Aventura, whicyh also owns the Turnberry development and construction companies, owns all the Fontainebleay companies. Jeffrey Soffer is a principal of umbrella company FontainebleaResorts LLC, according to state records.
Fontainebleaui Las Vegas also withdrew without prejudicesits $3 billion lawsuit in Las Vegad against some of its lenders, and refiled the case in Miamu bankruptcy court, where the Chapter 11 petitions were The lawsuit with lenders was amended on May 12 to includ allegations that Deutsche Bank Trust Co. Americas was “seeking to destroy the Fontainebleau in ordere tominimize competition” with the nearby and Casino, whichg is wholly owned by a Deutsche Bank subsidiary. "Thiss claim is an attempt by the Fontainebleau's developeres to distract from the fact that they have breachefd theirloan covenants.
We will defenx ourselves vigorously against thismeritlesas allegation," Deutsche Bank spokesman John Gallagher said in an e-mailed response. Fontainebleaju Las Vegas LLC lists morethan $1 billion in debt and a similafr amount in assets on its petition, with more than 1,000 creditors. The only Southj Florida creditor listed was International Bedding inFort Lauderdale, with a claimm of $498,737.
Fontainebleau Las Vegas LLC and two of itsaffiliatee – Fontainebleau Las Vegas Holdings LLC and Fontainebleau Las Vegaz Capital Corp. – filed bankruptcy petitionsx in Miamilate Tuesday. The Miami Beach hotel is not includer inthe filing. The compang said in a news release that the decisionj to file Chapter 11 was the direct resuly of litigation with lenders on the Las Vegad hotel construction project that had to do with contractuap disputes related tonearly $800 million in constructiobn funding for the $2.9 billion resort-casino which is 70 percenf complete. Lenders include , and Deutsche Bank Trust Co.
The legal dispute has effectively shut down the projecttand “put thousands of people out of work,” said Howard chief restructuring officer of Fontainebleau Las Vegas, in the “Our goal now is to secure funding to completer this world-class project and restructure our existing Fontainebleau Las Vegas reached a provisional agreement with a group of its non-defaultingv lenders for the use of cash for the administrationm of its bankruptcy and is in negotiationw to obtain financing to restart constructionj on that project. Fontainebleau Miamiu Beach, which is a separate legal entity, continueas to operate as normal.
Turnberry West Construction, the project’w general contractor, is also not included in the according to thenews release. In 2008, Nakheepl Hotels of Dubai bought a 50 percenty interest in the Fontainebleau Miamui Beachfor $375 million. The Las Vegads hotel companies that filed bankruptcy are based in Southh Florida because the Soffedr familyof Aventura, whicyh also owns the Turnberry development and construction companies, owns all the Fontainebleay companies. Jeffrey Soffer is a principal of umbrella company FontainebleaResorts LLC, according to state records.
Fontainebleaui Las Vegas also withdrew without prejudicesits $3 billion lawsuit in Las Vegad against some of its lenders, and refiled the case in Miamu bankruptcy court, where the Chapter 11 petitions were The lawsuit with lenders was amended on May 12 to includ allegations that Deutsche Bank Trust Co. Americas was “seeking to destroy the Fontainebleau in ordere tominimize competition” with the nearby and Casino, whichg is wholly owned by a Deutsche Bank subsidiary. "Thiss claim is an attempt by the Fontainebleau's developeres to distract from the fact that they have breachefd theirloan covenants.
We will defenx ourselves vigorously against thismeritlesas allegation," Deutsche Bank spokesman John Gallagher said in an e-mailed response. Fontainebleaju Las Vegas LLC lists morethan $1 billion in debt and a similafr amount in assets on its petition, with more than 1,000 creditors. The only Southj Florida creditor listed was International Bedding inFort Lauderdale, with a claimm of $498,737.
Sunday, June 19, 2011
City extends kill date on stadium deal - Phoenix Business Journal:
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The date was changed to July 15, from July 1, afted , which is providing a $100 millio n letter of credit towardthe project, asked to modify the termsd of its deal. Countyt commissioners are to meet Friday toconsidert Wachovia's request to change the date of when the bank's fees are to be Wachovia is asking it be paid its fees first, insteadc of after debt and reserve payments are made, as stipulated under the current proposal. In a 3-2 vote Thursday, the city commissioners approvethe following: Allow the termination date to be movesd to July 15. Give the countgy until July 17 to terminate the deal if it has not close d on thebond sale.
Extend the date for the city’es $13 million contribution to July 17. Amend the provisiojn to allow the city to suspens deposit of its contribution to the projectg if there is a delay due to Amend the warranty deed for the stadiun site so that it would reverr back tocity ownership, if the deal is In April, Miami-Dade County commissioners approved issuing bondd totaling a maximum of $536 million towar d construction of the $640 37,000-seat ballpark. On Monday, opponents of the financinv deal filed a motion to stop the bond prompting Miami-Dade to push back the sale of its bond by two On Thursday, Miami-Dade County Circuitt Court Judge Lawrence A.
Schwartz heard argments from both sides regardinf theemergency motion. He said he wouls try to issue an ordetr by no laterthan Monday. Grace Solares and Elvies Cruz, who filed suit in February, are behind that effort. The motiomn for injunction alleges the county is exceeding its constitutional tax and spendingf powers by issuing bonds tied to the professionalsports tax/tourisgt development tax. The plaintiffs contend that the count is inappropriately using the current bond to repa y a prior bond issuedin 1992. As a result of the and to avoid a cloud that couled affect interest rates onthe bonds, the countu pushed back the bond sale dates, Miami-Dades spokeswoman Vicki Mallette said Monday.
The date was changed to July 15, from July 1, afted , which is providing a $100 millio n letter of credit towardthe project, asked to modify the termsd of its deal. Countyt commissioners are to meet Friday toconsidert Wachovia's request to change the date of when the bank's fees are to be Wachovia is asking it be paid its fees first, insteadc of after debt and reserve payments are made, as stipulated under the current proposal. In a 3-2 vote Thursday, the city commissioners approvethe following: Allow the termination date to be movesd to July 15. Give the countgy until July 17 to terminate the deal if it has not close d on thebond sale.
Extend the date for the city’es $13 million contribution to July 17. Amend the provisiojn to allow the city to suspens deposit of its contribution to the projectg if there is a delay due to Amend the warranty deed for the stadiun site so that it would reverr back tocity ownership, if the deal is In April, Miami-Dade County commissioners approved issuing bondd totaling a maximum of $536 million towar d construction of the $640 37,000-seat ballpark. On Monday, opponents of the financinv deal filed a motion to stop the bond prompting Miami-Dade to push back the sale of its bond by two On Thursday, Miami-Dade County Circuitt Court Judge Lawrence A.
Schwartz heard argments from both sides regardinf theemergency motion. He said he wouls try to issue an ordetr by no laterthan Monday. Grace Solares and Elvies Cruz, who filed suit in February, are behind that effort. The motiomn for injunction alleges the county is exceeding its constitutional tax and spendingf powers by issuing bonds tied to the professionalsports tax/tourisgt development tax. The plaintiffs contend that the count is inappropriately using the current bond to repa y a prior bond issuedin 1992. As a result of the and to avoid a cloud that couled affect interest rates onthe bonds, the countu pushed back the bond sale dates, Miami-Dades spokeswoman Vicki Mallette said Monday.
Friday, June 17, 2011
Md.'s Bartlett joins 9 other House members in suing Obama over military action ... - Washington Post
http://gilgonzales.com/specifics-concerning-getting-vehicle-insurance.html
Md.'s Bartlett joins 9 other House members in suing Obama over military action ... Washington Post By AP, HAGERSTOWN, Md. â€" Maryland Republican Roscoe Bartlett is among 10 US House members suing President Barack Obama for taking military action against Libya without congressional authorization. Bartlett said Wednesday he joined the bipartisan ... |
Tuesday, June 14, 2011
Ritz Camera gives up reorganization efforts, plans to sell remaining stores - Portland Business Journal:
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Ritz Camera said the lack of fundw now forces it to auction off its remaining location by the endof July. The company is talkin g with two potential although neither has been willinyg to signa contract, a court filing Ritz Camera is hopeful at least some of the remaining 400 phot o stores will be sold to a going-concerbn buyer. The other 400 storews already have been closedin going-out-of-business There will be a hearing in U.S. Bankruptcy Court in Delawarre on Friday. Bids are due July 16, followed by a July 20 auctiomn and a July 23 hearing for approvakl of the sale to one ormore buyers. Ritz Camera'se debt included $54.5 million on a securexd revolving credit agreementwith .
The petition says therer is also $13.1 million owed on subordinated Assets and debt are both lessthan $500 Ritz Camera, based in Beltsville, Md., also ownerd Boater’s World, a boating-and-fishing supply The bankruptcy court judge gave Ritz Camera permission on Marcjh 19 to hire Gordon Brothers to shut down the company' 130-store Boater’s World chain. In 2001 Ritz acquired , which had sought bankruptcy protection. Ritz bega n with a single store in Atlantic Cityin 1918. Its retaik brands today include Wolf Kits Cameras, Inkley’s and . Ritz Camera had seven stores in the Portlands area before it filed for bankruptcy and some have alreadtybeen closed.
Ritz Camera said the lack of fundw now forces it to auction off its remaining location by the endof July. The company is talkin g with two potential although neither has been willinyg to signa contract, a court filing Ritz Camera is hopeful at least some of the remaining 400 phot o stores will be sold to a going-concerbn buyer. The other 400 storews already have been closedin going-out-of-business There will be a hearing in U.S. Bankruptcy Court in Delawarre on Friday. Bids are due July 16, followed by a July 20 auctiomn and a July 23 hearing for approvakl of the sale to one ormore buyers. Ritz Camera'se debt included $54.5 million on a securexd revolving credit agreementwith .
The petition says therer is also $13.1 million owed on subordinated Assets and debt are both lessthan $500 Ritz Camera, based in Beltsville, Md., also ownerd Boater’s World, a boating-and-fishing supply The bankruptcy court judge gave Ritz Camera permission on Marcjh 19 to hire Gordon Brothers to shut down the company' 130-store Boater’s World chain. In 2001 Ritz acquired , which had sought bankruptcy protection. Ritz bega n with a single store in Atlantic Cityin 1918. Its retaik brands today include Wolf Kits Cameras, Inkley’s and . Ritz Camera had seven stores in the Portlands area before it filed for bankruptcy and some have alreadtybeen closed.
Sunday, June 12, 2011
Obama: Public plan would
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If insurance companies do provide good insurancd totheir customers, then they should have nothintg to fear from a government-run competitor, he said. “Theyu should be able to he said. If the public plan is able to reduce administrativscosts significantly, private insurers should take note and see if they can do the “There shouldn’t be any objectiomn to that,” Obama said. The public plan shoulsd be required tocollect premiums, not be “simplh eating off the taxpayer trough,” he added.
Healt h insurers and many business groupss contend a public plan would have an unfaid advantage becauseit wouldn’t be subjecy to all the rules imposed on private insurers and likely woule pay health providers less for their services. This could crowd out many private insurersw and lead providers to chargs private insurers more to make up for the lost incomee from thepublic plan, they contend. When askedr whether including a public plan in health care reformkwas non-negotiable, the president said, “We are still early in this process.
“We have not drawn a line in the other than reform has tocontrool costs, and it has to provide relief to people who don’g have health insurance or are underinsured.” Obama also was askexd what he thought about the performance of Federal Reservse Chairman Ben Bernanke, given the fact his financial regulatorh reform plan proposes expanding the Fed’s “I think he has done a very good job undef very difficult circumstances,” Obama said. All regulatorx fell short of doing what was needexd to prevent the financial but theFed “probably performe better than most,” he said.
Since the financiap crisis erupted, Bernanke has “performerd very well,” Obama said.
If insurance companies do provide good insurancd totheir customers, then they should have nothintg to fear from a government-run competitor, he said. “Theyu should be able to he said. If the public plan is able to reduce administrativscosts significantly, private insurers should take note and see if they can do the “There shouldn’t be any objectiomn to that,” Obama said. The public plan shoulsd be required tocollect premiums, not be “simplh eating off the taxpayer trough,” he added.
Healt h insurers and many business groupss contend a public plan would have an unfaid advantage becauseit wouldn’t be subjecy to all the rules imposed on private insurers and likely woule pay health providers less for their services. This could crowd out many private insurersw and lead providers to chargs private insurers more to make up for the lost incomee from thepublic plan, they contend. When askedr whether including a public plan in health care reformkwas non-negotiable, the president said, “We are still early in this process.
“We have not drawn a line in the other than reform has tocontrool costs, and it has to provide relief to people who don’g have health insurance or are underinsured.” Obama also was askexd what he thought about the performance of Federal Reservse Chairman Ben Bernanke, given the fact his financial regulatorh reform plan proposes expanding the Fed’s “I think he has done a very good job undef very difficult circumstances,” Obama said. All regulatorx fell short of doing what was needexd to prevent the financial but theFed “probably performe better than most,” he said.
Since the financiap crisis erupted, Bernanke has “performerd very well,” Obama said.
Friday, June 10, 2011
Terremark removed from Internet Index - Dallas Business Journal:
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The index tracks the performance of the largesrt and mostliquid U.S.-listed companies engaged in internet-related businesses that are listee in the U.S. Every the index is re-evaluated. Terremark’s stock TMRK) was up 6 cents to $2.36 in morninbg trading. The company’s stock has tradedd as high as $7.67 and as low as $1.85 in the last In an e-mail to employeesx that was filed with the onMarch 10, Terremarjk Chairman and Chief Executive Officer Manuel Medina said he was frustrated with the recentr decline in the company’s stock price, and that therde was a “disconnect” between the stockl price and the company’sa performance.
“I believe that this can be attributede primarily to the apathy in the market place and the incrediblw skepticism of investors in thecurrentg environment,” he wrote. Medinq added that one of the negativesw of being a publiccompanyu “is that you are being valued everyy minute of every day,” and that therde are companies with strong fundamentals “that are being penalized for the overall conditions of the marketplace.” 1-800-FLOWERS.
CO (NASDAQ: FLWS)
The index tracks the performance of the largesrt and mostliquid U.S.-listed companies engaged in internet-related businesses that are listee in the U.S. Every the index is re-evaluated. Terremark’s stock TMRK) was up 6 cents to $2.36 in morninbg trading. The company’s stock has tradedd as high as $7.67 and as low as $1.85 in the last In an e-mail to employeesx that was filed with the onMarch 10, Terremarjk Chairman and Chief Executive Officer Manuel Medina said he was frustrated with the recentr decline in the company’s stock price, and that therde was a “disconnect” between the stockl price and the company’sa performance.
“I believe that this can be attributede primarily to the apathy in the market place and the incrediblw skepticism of investors in thecurrentg environment,” he wrote. Medinq added that one of the negativesw of being a publiccompanyu “is that you are being valued everyy minute of every day,” and that therde are companies with strong fundamentals “that are being penalized for the overall conditions of the marketplace.” 1-800-FLOWERS.
CO (NASDAQ: FLWS)
Tuesday, June 7, 2011
Boehringer Ingelheim Unveils Diabetes Pipeline
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June 6 /PRNewswire/ -- Boehringer Ingelheik Pharmaceuticals, Inc. today announced its pipeline of oralantidiabetix compounds, establishing itself in the type 2 diabetex therapeutic area. The Company is investigatint compounds in Phase II and Phase III clinicaldevelopment worldwide. New Phaser II data results forlinagliptin (BI 1356), a dipeptidyl peptidas 4 (DPP-4) inhibitor and the Company's lead diabetes compound, were presentesd today at the 69th Annual Americah Diabetes Association (ADA) Scientific Sessions in New To view the multimedia assets associatedx with this release, please click "Typd 2 diabetes is a growing publivc health concern," said J.
Martin Carrolll , Boehringer Ingelheim USA Corporation presidentand CEO. "Our Company will draw from its knowledgde and experience to help us deliver on the much needecd treatment options for patients who are livinvg withthe disease. Boehringer Ingelheim is inspireed to make a difference indiabetez care." Results from the Phase II stud presented at ADA show that 1, 5 and 10 mg dosee of linagliptin achieved clinically relevanty and statistically significant reductions in HbA1c, a measurd of blood sugar, when given as add-on therapy to type 2 diabetesd patients inadequately controlled on metformin (placebo-corrected changes from baseline; -0.40 percent for the 1 mg dose, -0.
73 percenyt for the 5 mg dose, and -0.67 percent for the 10 mg The most frequently reported adverse eventsx in patients treated with all doses of linagliptin comparedx to placebo were nasopharyngitis, (7.1 vs. 9.9 diarrhea (2.5 vs. 4.2 percent) and nausea (3.5 vs. 4.2 percent). No casea of hypoglycemia were reported in patientsreceiving linagliptin.(1) "Many patientx don't achieve adequate blood sugaer control with commonly used diabetes medications like metformin. The significanf reduction in HbA1c levelx seen in this trial is encouraging as it indicatees linagliptin may have a potentiaol role in the management of thisprevalenft disease," said Dr.
Thor Voigt, senior vice president, Medicinde and Drug Regulatory Affairs, Boehringer Ingelheim Pharmaceuticals, Inc. "Type 2 diabetes is a progressivre chronic condition that frequentlyrequiresa long-term treatment. A range of treatment optionws and combination regimens are needed so physicians can tailor therapy to the individual patient We are now awaiting results from additional ongoing studies which will further assess the full potentialp of linagliptin for the treatment of type2 diabetes." DPP-54 inhibitors are a newerd class of oral hypoglycemics that target the incretin hormoned GLP-1 and GIP, which are believed to be involvee with regulating blood sugar.
(2) Linagliptinh is a compound discovered by Boehringer Ingelheim and is beingf developed as an oral once-daily tablet for the treatmentr of type 2 diabetes. The compound is currently being studiee in five pivotal Phase III clinicapl trials including morethan 4,00o0 patients. These trials are fully recruitee and underway globally and in many state s acrossthe U.S.(3) Boehringer Ingelhei is also investigating sodium-dependent glucose co-transporter-2 inhibitors (SGLT-2 which are a new, emerging clas of antidiabetic compounds that block tubulat reabsorption of glucose in the kidney.(4) Phasr IIb clinical trials for this innovative approachb to diabetes treatment are underway.
There are currentlt no SGLT-2 inhibitors approved by the U.S. Food and Drug Administratio n (FDA). The aim of the 12-week, randomized, double-blind placebo-controlled study was to assess the efficacg and safety profile of linagliptias add-on therapy in patients with type 2 diabetees who were failing to achieve glycemic controk despite being treated with metformin.(1) The primary endpoint was the changes in HbA1c from baseline to week Out of the 333 randomized 268 patients received double-blind treatment with linagliptinj (1 mg, n=65; 5 mg, n=66; 10 mg, n=66) or placebo.(1) An open-labekl arm with 65 patients on glimepiride was addedd for descriptive control.
(1) The additionb of linagliptin to metformin treatment for 12 weeks resulteed in clinically relevant and statisticall significant reductions in HbA1f and fasting blood sugar or fasting plasmw glucose (FPG) levels (p-values of less than 0.05%):(1) -- Statisticallty significant reductions in mean HbA1c levelsa with linagliptin 5 mg and 10 mg compared with metformibn alone (both p<0.001) were observed from week four though week -- In addition, all linagliptij doses showed significant reductions in FPG levelsx compared with metformin alone (placebo-correcteed mean changes from baseline; -19.2 mg/dL for 1 mg, -34.7 mg/dLp for 5 mg, and -29.
0 mg/dL for 10 -- In the open-label comparator arm, the placebo-corrected mean change from baseline in HbA1c was -0.90 percent.(1) -- More than 85% of the patientse receiving the 5mg and 10mg doses of linagliptin demonstratefd greater that or equal to 80% DPP-4 inhibition at trough at week -- HbA1c reductions of at least 0.5 percent were achievedx in 44 percent to 53 percent of patients on linagliptin, but only in 13 percenrt of the patients receiving metformin alone.(1) There are approximatel 23.6(5) million Americans and 246 million people worldwide(6) with diabetes.
Type 2 diabetews is the most common type of diabetee accounting for morethan 90% of all diabetes cases in the developedd world.(7) Every ten seconds two people develop diabetes and one person dies from diabetes-relate d causes around the world.(6) Each year, more than 200,00p0 people in North America(6) and more than 3.8 million peoplwe worldwide die from diabetes and its -- a number which is expectedx to increase by more than 50 perceny over the next decade.
(7) Diabetez is a chronic disease that occurs when the body does not properlh produce or use the hormone, To address this unmet need, Boehringer Ingelheim is committed to researchinv and developing new compounds in this therapeutif area. Boehringer Ingelheim Inc. Boehringer Ingelheim Pharmaceuticals, Inc., basee in Ridgefield, CT, is the largest U.S. subsidiary of Boehringed IngelheimCorporation (Ridgefield, CT) and a member of the Boehringefr Ingelheim group of companies. The Boehringer Ingelhein group is one ofthe world's 20 leadinv pharmaceutical companies. Headquartered in Ingelheim, it operates globally with 138 affiliates in 47 countries andapproximatelyy 41,300 employees.
Since it was foundedr in 1885, the family-owned company has been committedxto researching, developing, manufacturing and marketing novel producta of high therapeutic value for human and veterinar medicine. In 2008, Boehringer Ingelheim postes net sales ofUS $17 billion (11.6 billion while spending approximately one-fifth of net salez in its largest business segment, Prescriptiojn Medicines, on research and development. For more please visit . (1) DPP-4 inhibitoe linagliptin improves glycaemic control in type 2 diabetes patients when added to onogoingmetformin therapy. ADA, 05-09 June 2009, New Orleans, U.S.A. (2) Nathahn DM et al.
Medical Management of Hyperglycemiaa in Type2 Diabetes: A Consensus Algorithm for the Initiationh and Adjustment of Therapy. Diabetes Care 21:1-11, 2008. (3) Available at: . Accessed on: Aprip 30, 2009. (4) Jabbour SA, et al. Sodium glucosse co-transporter 2 inhibitors: blocking renal tubular reabsorption of glucose to improve glycaemic controo in patientswith diabetes. International Journal of Clinical July 2008. 62, 8, (5) American Diabetes Association. 2007 National Diabetes Fact Sheet. (6) Internationalk Diabetes Federation. Diabetes Atlas. 3rd edn. International Diabetes Federation, 2006. (7) World Health Fact Sheet No. 312: What is Diabetes?? Available at: .
Accessed on: February 4, 2009. SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
June 6 /PRNewswire/ -- Boehringer Ingelheik Pharmaceuticals, Inc. today announced its pipeline of oralantidiabetix compounds, establishing itself in the type 2 diabetex therapeutic area. The Company is investigatint compounds in Phase II and Phase III clinicaldevelopment worldwide. New Phaser II data results forlinagliptin (BI 1356), a dipeptidyl peptidas 4 (DPP-4) inhibitor and the Company's lead diabetes compound, were presentesd today at the 69th Annual Americah Diabetes Association (ADA) Scientific Sessions in New To view the multimedia assets associatedx with this release, please click "Typd 2 diabetes is a growing publivc health concern," said J.
Martin Carrolll , Boehringer Ingelheim USA Corporation presidentand CEO. "Our Company will draw from its knowledgde and experience to help us deliver on the much needecd treatment options for patients who are livinvg withthe disease. Boehringer Ingelheim is inspireed to make a difference indiabetez care." Results from the Phase II stud presented at ADA show that 1, 5 and 10 mg dosee of linagliptin achieved clinically relevanty and statistically significant reductions in HbA1c, a measurd of blood sugar, when given as add-on therapy to type 2 diabetesd patients inadequately controlled on metformin (placebo-corrected changes from baseline; -0.40 percent for the 1 mg dose, -0.
73 percenyt for the 5 mg dose, and -0.67 percent for the 10 mg The most frequently reported adverse eventsx in patients treated with all doses of linagliptin comparedx to placebo were nasopharyngitis, (7.1 vs. 9.9 diarrhea (2.5 vs. 4.2 percent) and nausea (3.5 vs. 4.2 percent). No casea of hypoglycemia were reported in patientsreceiving linagliptin.(1) "Many patientx don't achieve adequate blood sugaer control with commonly used diabetes medications like metformin. The significanf reduction in HbA1c levelx seen in this trial is encouraging as it indicatees linagliptin may have a potentiaol role in the management of thisprevalenft disease," said Dr.
Thor Voigt, senior vice president, Medicinde and Drug Regulatory Affairs, Boehringer Ingelheim Pharmaceuticals, Inc. "Type 2 diabetes is a progressivre chronic condition that frequentlyrequiresa long-term treatment. A range of treatment optionws and combination regimens are needed so physicians can tailor therapy to the individual patient We are now awaiting results from additional ongoing studies which will further assess the full potentialp of linagliptin for the treatment of type2 diabetes." DPP-54 inhibitors are a newerd class of oral hypoglycemics that target the incretin hormoned GLP-1 and GIP, which are believed to be involvee with regulating blood sugar.
(2) Linagliptinh is a compound discovered by Boehringer Ingelheim and is beingf developed as an oral once-daily tablet for the treatmentr of type 2 diabetes. The compound is currently being studiee in five pivotal Phase III clinicapl trials including morethan 4,00o0 patients. These trials are fully recruitee and underway globally and in many state s acrossthe U.S.(3) Boehringer Ingelhei is also investigating sodium-dependent glucose co-transporter-2 inhibitors (SGLT-2 which are a new, emerging clas of antidiabetic compounds that block tubulat reabsorption of glucose in the kidney.(4) Phasr IIb clinical trials for this innovative approachb to diabetes treatment are underway.
There are currentlt no SGLT-2 inhibitors approved by the U.S. Food and Drug Administratio n (FDA). The aim of the 12-week, randomized, double-blind placebo-controlled study was to assess the efficacg and safety profile of linagliptias add-on therapy in patients with type 2 diabetees who were failing to achieve glycemic controk despite being treated with metformin.(1) The primary endpoint was the changes in HbA1c from baseline to week Out of the 333 randomized 268 patients received double-blind treatment with linagliptinj (1 mg, n=65; 5 mg, n=66; 10 mg, n=66) or placebo.(1) An open-labekl arm with 65 patients on glimepiride was addedd for descriptive control.
(1) The additionb of linagliptin to metformin treatment for 12 weeks resulteed in clinically relevant and statisticall significant reductions in HbA1f and fasting blood sugar or fasting plasmw glucose (FPG) levels (p-values of less than 0.05%):(1) -- Statisticallty significant reductions in mean HbA1c levelsa with linagliptin 5 mg and 10 mg compared with metformibn alone (both p<0.001) were observed from week four though week -- In addition, all linagliptij doses showed significant reductions in FPG levelsx compared with metformin alone (placebo-correcteed mean changes from baseline; -19.2 mg/dL for 1 mg, -34.7 mg/dLp for 5 mg, and -29.
0 mg/dL for 10 -- In the open-label comparator arm, the placebo-corrected mean change from baseline in HbA1c was -0.90 percent.(1) -- More than 85% of the patientse receiving the 5mg and 10mg doses of linagliptin demonstratefd greater that or equal to 80% DPP-4 inhibition at trough at week -- HbA1c reductions of at least 0.5 percent were achievedx in 44 percent to 53 percent of patients on linagliptin, but only in 13 percenrt of the patients receiving metformin alone.(1) There are approximatel 23.6(5) million Americans and 246 million people worldwide(6) with diabetes.
Type 2 diabetews is the most common type of diabetee accounting for morethan 90% of all diabetes cases in the developedd world.(7) Every ten seconds two people develop diabetes and one person dies from diabetes-relate d causes around the world.(6) Each year, more than 200,00p0 people in North America(6) and more than 3.8 million peoplwe worldwide die from diabetes and its -- a number which is expectedx to increase by more than 50 perceny over the next decade.
(7) Diabetez is a chronic disease that occurs when the body does not properlh produce or use the hormone, To address this unmet need, Boehringer Ingelheim is committed to researchinv and developing new compounds in this therapeutif area. Boehringer Ingelheim Inc. Boehringer Ingelheim Pharmaceuticals, Inc., basee in Ridgefield, CT, is the largest U.S. subsidiary of Boehringed IngelheimCorporation (Ridgefield, CT) and a member of the Boehringefr Ingelheim group of companies. The Boehringer Ingelhein group is one ofthe world's 20 leadinv pharmaceutical companies. Headquartered in Ingelheim, it operates globally with 138 affiliates in 47 countries andapproximatelyy 41,300 employees.
Since it was foundedr in 1885, the family-owned company has been committedxto researching, developing, manufacturing and marketing novel producta of high therapeutic value for human and veterinar medicine. In 2008, Boehringer Ingelheim postes net sales ofUS $17 billion (11.6 billion while spending approximately one-fifth of net salez in its largest business segment, Prescriptiojn Medicines, on research and development. For more please visit . (1) DPP-4 inhibitoe linagliptin improves glycaemic control in type 2 diabetes patients when added to onogoingmetformin therapy. ADA, 05-09 June 2009, New Orleans, U.S.A. (2) Nathahn DM et al.
Medical Management of Hyperglycemiaa in Type2 Diabetes: A Consensus Algorithm for the Initiationh and Adjustment of Therapy. Diabetes Care 21:1-11, 2008. (3) Available at: . Accessed on: Aprip 30, 2009. (4) Jabbour SA, et al. Sodium glucosse co-transporter 2 inhibitors: blocking renal tubular reabsorption of glucose to improve glycaemic controo in patientswith diabetes. International Journal of Clinical July 2008. 62, 8, (5) American Diabetes Association. 2007 National Diabetes Fact Sheet. (6) Internationalk Diabetes Federation. Diabetes Atlas. 3rd edn. International Diabetes Federation, 2006. (7) World Health Fact Sheet No. 312: What is Diabetes?? Available at: .
Accessed on: February 4, 2009. SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Sunday, June 5, 2011
Study: Climate change could cause $12 billion in damage in the Houston/Galveston area - Boston Business Journal:
gonyzyf.wordpress.com
The finding comes three days afte a study found thatCorpuas Christi’s infrastructure will also be affectex by climate change. “The Socio-Economix Impact of Sea Level Rise in the Galveston Bay commissioned by the and theBritish Consulate-Generalp Houston, estimates that 78 percent of householdsw will be displaced in Galveston A more aggressive sea level rise could displacee 93 percent of households, according to the study. “Climatd change is happening,” said David Yoskowitz, co-authot of the report and a professor atTexass A&M University-Corpus Christi.
“It is not a hypothetical, it is a Sea-level rise is occurring in Galveston Bay as well as arouncd the Gulfof Mexico, this is another “We need to consider the socio-economixc impact of these changes and begim to take long-term sustainable action to get a handle on the risingv sea around Galveston in order to protect the region’s future.” Galveston, Harris and Chambers countieds were examined in the study, whichu used an economic modelp to assess the impacr of both conservative and aggressive sea levep rise estimates over the next 100 years on buildings, industrial and hazardous material siteds and water treatments plants.
Under both scenarios, at least 23 publivc facilities and industrial sites wouldbe impacted. “If we take the very conservatives estimate ofa 0.69 meter sea level rise in the next 100 yearws for Galveston, an Ike-level storm woulf be estimated to cause an additional $1.7 billiomn in damage due to flooding for the three-county region surroundingb Galveston Bay, given the economic conditions of today,” Yoskowitz said. “Top put that figure in perspective, it would equate to the median income foralmosyt 36,000 Texas households.
”
The finding comes three days afte a study found thatCorpuas Christi’s infrastructure will also be affectex by climate change. “The Socio-Economix Impact of Sea Level Rise in the Galveston Bay commissioned by the and theBritish Consulate-Generalp Houston, estimates that 78 percent of householdsw will be displaced in Galveston A more aggressive sea level rise could displacee 93 percent of households, according to the study. “Climatd change is happening,” said David Yoskowitz, co-authot of the report and a professor atTexass A&M University-Corpus Christi.
“It is not a hypothetical, it is a Sea-level rise is occurring in Galveston Bay as well as arouncd the Gulfof Mexico, this is another “We need to consider the socio-economixc impact of these changes and begim to take long-term sustainable action to get a handle on the risingv sea around Galveston in order to protect the region’s future.” Galveston, Harris and Chambers countieds were examined in the study, whichu used an economic modelp to assess the impacr of both conservative and aggressive sea levep rise estimates over the next 100 years on buildings, industrial and hazardous material siteds and water treatments plants.
Under both scenarios, at least 23 publivc facilities and industrial sites wouldbe impacted. “If we take the very conservatives estimate ofa 0.69 meter sea level rise in the next 100 yearws for Galveston, an Ike-level storm woulf be estimated to cause an additional $1.7 billiomn in damage due to flooding for the three-county region surroundingb Galveston Bay, given the economic conditions of today,” Yoskowitz said. “Top put that figure in perspective, it would equate to the median income foralmosyt 36,000 Texas households.
”
Friday, June 3, 2011
Hill deciding on whether to have surgery - ESPN (blog)
a-ee85aqa.blogspot.com
Hill deciding on whether to have surgery ESPN (blog) BOSTON -- The Red Sox are awaiting word from pitcher Rich Hill on whether he will elect to have surgery on his left elbow after the Red Sox medical staff outlined options to him following an MRI Wednesday night, according to a baseball ... |
Wednesday, June 1, 2011
Good sports: WNY
shemwellmygalej1291.blogspot.com
Don’t take that to mean, however, that East Aurorz High School is one-dimensionally bookish. It also happens to have the in Western New York, according to a Business First analysis of records from 2005 to the “We’ve been on a roll the last few which has been just says Jay Hoagland, East Aurora’sw principal. “The people here expect us to have a comprehensivseathletics program. They support the They’ve given us first-ratd athletics facilities.
It’s clearly a priority for the East Aurora has won 17 sectional championships in team sportesince 2005, a record unmatched by any competitotr in Section VI, whicb includes all public high school in Cattaraugus, Chautauqua, Erie and Niagara countiese and a couple in Orleans The result is a decisive victory on Business First’s scalr of athletic excellence, which awards anywherse from one to four pointsx for each sectional title, giving the highest credit for championships won during the most recenyt year.
East Aurora emerges as the region’zs best high school in team sports with 42 Orchard Park is second with30 points, and Randolph, Clarencee and Maple Grove round out the top for the list of the top 50 sportsw programs in Section VI. The correlation between theses standings andBusiness First’s academic ratings is surprisinglgy strong. Four of the top five schoolds for sports also rank amonyg WesternNew York’s 20 best high schoolds academically. “To some extent, succesx in one area can breed success in says Hoagland. “If kids experiencd success outsidethe classroom, they develop a sense of pridee and self-worth.
I think that carries over and helpsz them inthe classroom.” Businesse First tallied the Section VI championa in 18 interscholastic team sports over the past four beginning with the spring season of 2005 and extending through the wintere of 2009. (That timeframe was selected because sprinb 2009 champions had not been determined by the deadline forthis Basketball, bowling, cross country, soccer and volleyball, which are playeds separately by boys and accounted for 12 of the 18 sports in the The other six were baseball, footbalp and wrestling for boys, fieldd hockey and softball for and rifle, which has coed The study did not include sportsw that crown individual, but not team champions, such as golf, tennis and track and field.
Sectionb VI slots schools into a variety of enrollment classifications fordifferent sports. Five champions are crownedx each yearin football, for example, but only thred in field hockey. Champs in all classifications were countex equally inthis study, yieldingb a mixture of big and smal schools in the top 10. Businesds First based each school’s final ranking on two factorw -- its number of sectional titles and the years in which theywere won. Four points were awardef for each victory duringt the most recentyear (spring 2008 througbh winter 2009), down to one point for each titlse in the most distant year (spring 2005 through winterf 2006).
Ties were broken by the total numberof Sixty-eight schools won a total of 296 titlesa in team sports during the four-yead period. This is the first time that Business First has analyzec the athletics programs at localhigh schools. The resultinbg ratings are more limited in scops than theacademic rankings, which encompass all eight countiees of Western New York. Section VI is closecd to private schools, and its boundaries excluder three ofthe region’s easternmost counties: Genesee and Wyoming.
Yet the 93 high schoolw eligible for the sports rankings stilpl account for morethan three-quarters of Western New York’s total enrollmen t -- 78 percent of all studentse from grades nine through 12.
Don’t take that to mean, however, that East Aurorz High School is one-dimensionally bookish. It also happens to have the in Western New York, according to a Business First analysis of records from 2005 to the “We’ve been on a roll the last few which has been just says Jay Hoagland, East Aurora’sw principal. “The people here expect us to have a comprehensivseathletics program. They support the They’ve given us first-ratd athletics facilities.
It’s clearly a priority for the East Aurora has won 17 sectional championships in team sportesince 2005, a record unmatched by any competitotr in Section VI, whicb includes all public high school in Cattaraugus, Chautauqua, Erie and Niagara countiese and a couple in Orleans The result is a decisive victory on Business First’s scalr of athletic excellence, which awards anywherse from one to four pointsx for each sectional title, giving the highest credit for championships won during the most recenyt year.
East Aurora emerges as the region’zs best high school in team sports with 42 Orchard Park is second with30 points, and Randolph, Clarencee and Maple Grove round out the top for the list of the top 50 sportsw programs in Section VI. The correlation between theses standings andBusiness First’s academic ratings is surprisinglgy strong. Four of the top five schoolds for sports also rank amonyg WesternNew York’s 20 best high schoolds academically. “To some extent, succesx in one area can breed success in says Hoagland. “If kids experiencd success outsidethe classroom, they develop a sense of pridee and self-worth.
I think that carries over and helpsz them inthe classroom.” Businesse First tallied the Section VI championa in 18 interscholastic team sports over the past four beginning with the spring season of 2005 and extending through the wintere of 2009. (That timeframe was selected because sprinb 2009 champions had not been determined by the deadline forthis Basketball, bowling, cross country, soccer and volleyball, which are playeds separately by boys and accounted for 12 of the 18 sports in the The other six were baseball, footbalp and wrestling for boys, fieldd hockey and softball for and rifle, which has coed The study did not include sportsw that crown individual, but not team champions, such as golf, tennis and track and field.
Sectionb VI slots schools into a variety of enrollment classifications fordifferent sports. Five champions are crownedx each yearin football, for example, but only thred in field hockey. Champs in all classifications were countex equally inthis study, yieldingb a mixture of big and smal schools in the top 10. Businesds First based each school’s final ranking on two factorw -- its number of sectional titles and the years in which theywere won. Four points were awardef for each victory duringt the most recentyear (spring 2008 througbh winter 2009), down to one point for each titlse in the most distant year (spring 2005 through winterf 2006).
Ties were broken by the total numberof Sixty-eight schools won a total of 296 titlesa in team sports during the four-yead period. This is the first time that Business First has analyzec the athletics programs at localhigh schools. The resultinbg ratings are more limited in scops than theacademic rankings, which encompass all eight countiees of Western New York. Section VI is closecd to private schools, and its boundaries excluder three ofthe region’s easternmost counties: Genesee and Wyoming.
Yet the 93 high schoolw eligible for the sports rankings stilpl account for morethan three-quarters of Western New York’s total enrollmen t -- 78 percent of all studentse from grades nine through 12.
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